|
MIB is a binding sites prediction server for metal ions, and this server provides an accurate, integrated method to search the residues in metal ion-binding sites by using the fragment transformation method. Eleven kinds of metal ions (Ca2+, Cu2+, Fe3+, Mg2+, Mn2+, Zn2+, Cd2+, Fe2+ ,Ni2+, Hg2+ and Co2+) binding residues prediction are supported. MIB also provides the metal ions modeling after prediction. Ultimately, for an FPR threshold of 5% our method achieved an overall 94.6% accuracy with a TPR of 60.5%, which is a substantial improvement over other prediction methods currently available. Therefore, our method may find use as a predictor of putative metal ion binding proteins and their binding.
|